Welcome to RGDtrip database.

The tripeptide Arginine-Glycine-Aspartic acid (RGD) is usually conformed as a loop and it can be found in all life forms, from virus to human. In homologous proteins it may or may not be conserved, the latter usually showing a change or loss of functionality. Its main function lies with proteins implicated to cell adhesion; the loop formation, however, with the charged side chains of D and R looking outwards and away from each other, constitutes a drastic and very distinct 3-D entity. This combination allows a wide range of bond-centered interactions, as in signal transduction. The RGD is routinely-though not exclusively- found in transmembranic proteins, usually faced outwards. Its functions are regulated by neighboring amino acids, which may provide either agility or rigidity.

The dispersion and abundance of RGD throughout the biosphere and the variety of its functions impose the need for massive data compilation and comparison to elucidate its role and impact.

To represent information in a form enabling interested parties to digest the large amounts of information without losing perspective, the RGDtrip proteins data collection provides users with advanced interface technology to complete and further their research an intuitive way.

See software requirements

Sofware requirements.

The software you need to access the application.

Microsoft Silverlight

In order to access the PivotViewer application you have installed Silverlight.

Internet Explorer

In order to access all operations use Internet Explorer browser.

Jmol java viewer

In order to access the Jmol viewer you will first have to install Java Software.

RGDtrip in action.

Learn how RGDtrip application works.

The team

Below are the people that they worked on this project.

Yiannis Hatzis1#, Emmanouil Viennas4#, Konstantinos Poulas1, Elias Eliopoulos2 and Giannis Tzimas3
were responsible for the database design and whole project.
Emmanouil Viennas4#, Yiannis Hatzis1# and Giannis Tzimas3
were responsible for the software development.
Trias Thireou2#, Vassilis Atlamazoglou2, Elias Eliopoulos2 and George K. Papadopoulos5
were responsible for the data acquisition.
Yiannis Hatzis1# and Trias Thireou2#
were responsible for manuscript preparation.

1 Department of Pharmacy, University of Patras
2 Department of Agricultural Biotechnology, Agricultural University of Athens
3 Department of Computer and Informatics Engineering, Technological Educational Institute of Western Greece
4 Department of Computer Engineering & Informatics, University of Patras
5 Department of Floriculture and Landscape Architecture, Epirus Institute of Technology
# equal contribution

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If you have any questions or need additional information, please send message.